SlimTune is a free profiler and performance analysis/tuning tool for .NET based applications, including C#, VB.NET, IronPython, and more. It provides many powerful features, such as remote profiling, real time results, multiple plugin-based visualizations, and much more. The source code is available under the terms of the MIT License.
SlimTune is currently in the prototyping phase of development, but a preview release is available for testing and feedback is welcome. Both x86 and x64 targets are supported, but only sampling based profiling is available in the release.
In this post on the DLR Codeplex forum Bill Chiles (DLR Program Manager) gives the bad news:
The DLR JScript was experimental for informing the design of the DLR (expression trees, interop, callsites, hosting, etc.). The JS we released with asp futures and the Silverlight dynamic sdk became very old and unserviceable as the DLR continued evolving for release in CLR 4.0. Unfortunately, there are no plans at this time to develop and release a DLR-hostable JScript.ctypes in IronPython 2.6. ctypes is the Python FFI and in IronPython it is built on top of PInvoke, the .NET FFI. ctypes is used for calling into native code, like the Win32 API. Calls SHGetFileInfoW, which "Retrieves information about an object in the file system, such as a file, folder, directory, or drive root."